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Formula Purposes & Benefits |
Bone Health Plus is developed based on cutting-edge scientific research and expert formulation to support joint health, cardiovascular health, immune health, and increased antioxidant status.
Bone Health Plus combines nature-sourced minerals, tocotrienols, and vitamin K2-7 in its preferred form to promote healthy bones and connective tissues. Prioritize your bone health with Premier Bone Health providing a comprehensive support for optimal bone and connective tissue well-being.
Our formula is proudly made in the USA in an FDA registered facility, following Good Manufacturing Practices (GMP) standards. Our commitment to excellence is reflected in the fact that only 4% of the supplements on the market can match our world-class standards. |
Bone Health Plus
Formula Ingredient Deck
Benefits Of Each Ingredient
Vitamin K2
- May support bone health, cardiovascular health, and Vitamin D metabolism (80,81).
- May support cardiovascular health via reduced atherosclerotic activity and minimizing calcium deposits in the blood vessels (80,81).
Aquamin
- May support osteogenesis, promoting bone formation and mineralization (390).
- May support antioxidant effects and the ability to induce apoptosis in U937 cells (392).
- May support enhanced gut microbial diversity, potentially promoting digestive health (393).
- May support improvements in lipid profiles, including potentially lowering LDL cholesterol levels (394).
Calcium
- May support bone health, muscle function, and cardiovascular health (36,37).
- Regulates processes of bone resorption, mineralization, and fracture repair (36,37).
- Increases the effect of physical exercise on bone mineral acquisition in the period preceding puberty (36,37).
- May reduce the development of preeclampsia (36,37).
Organic Chlorella
- May support antioxidant function through its high levels of carotenoids, which can protect against DNA damage and scavenge free radicals (265).
- May support cardiovascular health by potentially reducing cholesterol and triglyceride levels (265).
- May support detoxification by aiding in the removal of methylmercury from the body (265).
- May potentially combat depression by helping to reduce oxidative stress in the brain (266).
Organic Prickly Pear
- May support immune health via redox balance, decreased oxidative damage to lipids, and improved antioxidant status in healthy humans (368).
Reishi
- May support immune health, antioxidant activity, balanced estrogen levels, antiviral support, antibacterial, reduced stress, improved exercise performance, and blood sugar regulation (194,195).
- May support immune health via high concentrations of betagluxans which increase natural killer cell activity and t-cell mediated immunity (194).
Tocotrienols
- May support immune function, cognitive health, cardiovascular health, and bone health (204,205,206,207,208)
- May support immune health via neutralizing free radicals and reactive oxygen species, and increased T lymphocyte-mediated immune function (204).
- May support cardiovascular health via reduced cholesterol (204).
- May support cognitive function via reduced oxidative stress, inflammation, and DNA damage of neuronal tissues (208).
Organic Parsley
- May support immune health, antioxidant activity, and aids in the detoxification process (203,204).
Organic Turmeric
- May support antioxidant, cardio-protective, anti-inflammatory, anti-microbial, nephro-protective, hepato-protective, immunomodulatory, and anti-rheumatic effects (123).
- May reduce inflammation via decreases of inflammatory markers such as c-reactive protein, interleukin 6, tumor necrosis factor, and decreased cytokine production (123).
- May support joint health via decreases in connective tissue inflammation and improved pain in individuals with osteoarthritis (122).
- May support blood sugar regulation via increased pancreatic beta cell function and improved insulin sensitivity (121).
- May support cardiovascular and liver health via reduced accumulation of advanced glycation end products (AGE), reduced lipid peroxidation, and improved vascular function.
- Curcumin may exhibit antioxidant activity via scavenging of superoxide anion (∙O2−∙) and hydroxyl radicals (∙OH) (scavenging of inflammation molecules) (118,119).
- Curcumin may modulate breast carcinogenesis through its effect on cell cycle and proliferation, apoptosis, senescence, cancer spread and angiogenesis (119).
- May target cancer growth pathways such as the NFkB, PI3K/Akt/mTOR, MAPK and JAK/STAT (119).
Organic Alfalfa
- May support immune, digestive, and energy levels (395).
- The high antioxidant capacity may allow for free radical scavenging of reactive oxygen species (395).
- May support liver health via reduced fatty acid accumulation in the liver (395).
Frankincense
- May supports immune health, joint health, joint pain, and healthy inflammation levels (117,124, 125,400).
- Reduces inflammation via decreases in c-reactive protein, decreased arthritis in osteoarthritic patients, and reduced joint stiffness (124,400).
- Extracts of Boswellia have suppressed inflammation via local tissue tumor necrosis factor-α (TNFα) and interleukin-1β (IL-1β) (125,400).
Proper Use of This Supplement
Suggested Use: Take 3 capsules daily or as directed by a health professional.
Our Formula
Vs Other Formulas on the Market.
1. Uses third party independently tested ingredients that are made in the USA, GMP certified, and made in an FDA registered facility.
1. Source cheap ingredients from heavily polluted soils. Even “organic” supplements not third party tested have been removed by FDA due to high levels of heavy metals.
2. High quality bone support herbs and vitamin k-2 in a bioavailable and efficaciously dosed formula.
2. Uses cheap synthetic sources of bone support herbs that may have heavy metals due to poor product quality and lack of third-party lab testing for heavy metals.
36. Khaing, W., Vallibhakara, S. A., Tantrakul, V., Vallibhakara, O., Rattanasiri, S., McEvoy, M., Attia, J., & Thakkinstian, A. (2017). Calcium and Vitamin D Supplementation for Prevention of Preeclampsia: A Systematic Review and Network Meta-Analysis. Nutrients, 9(10), 1141. https://doi.org/10.3390/nu9101141
37. Courteix, D., Jaffré, C., Lespessailles, E., & Benhamou, L. (2005). Cumulative effects of calcium supplementation and physical activity on bone accretion in premenarchal children: a double-blind randomised placebo-controlled trial. International journal of sports medicine, 26(5), 332–338. https://doi.org/10.1055/s-2004-821040
116. Jovic, T. H., Ali, S. R., Ibrahim, N., Jessop, Z. M., Tarassoli, S. P., Dobbs, T. D., Holford, P., Thornton, C. A., & Whitaker, I. S. (2020). Could Vitamins Help in the Fight Against COVID-19?. Nutrients, 12(9), 2550. https://doi.org/10.3390/nu12092550
117. Chilelli, N. C., Ragazzi, E., Valentini, R., Cosma, C., Ferraresso, S., Lapolla, A., & Sartore, G. (2016). Curcumin and Boswellia serrata Modulate the Glyco-Oxidative Status and Lipo-Oxidation in Master Athletes. Nutrients, 8(11), 745. https://doi.org/10.3390/nu8110745
118. Barzegar, A., & Moosavi-Movahedi, A. A. (2011). Intracellular ROS protection efficiency and free radical-scavenging activity of curcumin. PloS one, 6(10), e26012. https://doi.org/10.1371/journal.pone.0026012
119. Banik, U., Parasuraman, S., Adhikary, A. K., & Othman, N. H. (2017). Curcumin: the spicy modulator of breast carcinogenesis. Journal of experimental & clinical cancer research : CR, 36(1), 98. https://doi.org/10.1186/s13046-017-0566-5
120. Suhett, L. G., de Miranda Monteiro Santos, R., Silveira, B., Leal, A., de Brito, A., de Novaes, J. F., & Lucia, C. (2021). Effects of curcumin supplementation on sport and physical exercise: a systematic review. Critical reviews in food science and nutrition, 61(6), 946–958. https://doi.org/10.1080/10408398.2020.1749025
121. Pivari, F., Mingione, A., Brasacchio, C., & Soldati, L. (2019). Curcumin and Type 2 Diabetes Mellitus: Prevention and Treatment. Nutrients, 11(8), 1837. https://doi.org/10.3390/nu11081837
122. Ashtary-Larky, D., Rezaei Kelishadi, M., Bagheri, R., Moosavian, S. P., Wong, A., Davoodi, S. H., Khalili, P., Dutheil, F., Suzuki, K., & Asbaghi, O. (2021). The Effects of Nano-Curcumin Supplementation on Risk Factors for Cardiovascular Disease: A GRADE-Assessed Systematic Review and Meta-Analysis of Clinical Trials. Antioxidants (Basel, Switzerland), 10(7), 1015. https://doi.org/10.3390/antiox10071015
123. Mata, I., Mata, S., Menezes, R., Faccioli, L. S., Bandeira, K. K., & Bosco, S. (2020). Benefits of turmeric supplementation for skin health in chronic diseases: a systematic review. Critical reviews in food science and nutrition, 1–15. Advance online publication. https://doi.org/10.1080/10408398.2020.1798353
194. Hetland G, Tangen JM, Mahmood F, Mirlashari MR, Nissen-Meyer LSH, Nentwich I, Therkelsen SP, Tjønnfjord GE, Johnson E. Antitumor, Anti-Inflammatory and Antiallergic Effects of Agaricus blazei Mushroom Extract and the Related Medicinal Basidiomycetes Mushrooms, Hericium erinaceus and Grifolafrondosa: A Review of Preclinical and Clinical Studies. Nutrients. 2020 May 8;12(5):1339. doi: 10.3390/nu12051339. PMID: 32397163; PMCID: PMC7285126.
195. Mallard B, Leach DN, Wohlmuth H, Tiralongo J. Synergistic immuno-modulatory activity in human macrophages of a medicinal mushroom formulation consisting of Reishi, Shiitake and Maitake. PLoS One. 2019 Nov 7;14(11):e0224740. doi: 10.1371/journal.pone.0224740. PMID: 31697749; PMCID: PMC6837746.
203. Mara de Menezes Epifanio, N., Rykiel Iglesias Cavalcanti, L., Falcão Dos Santos, K., Soares Coutinho Duarte, P., Kachlicki, P., Ożarowski, M., Jorge Riger, C., & Siqueira de Almeida Chaves, D. (2020). Chemical characterization and in vivo antioxidant activity of parsley (Petroselinum crispum) aqueous extract. Food & function, 11(6), 5346–5356. https://doi.org/10.1039/d0fo00484g
205. Traber, M. G., & Atkinson, J. (2007). Vitamin E, antioxidant and nothing more. Free radical biology & medicine, 43(1), 4–15. https://doi.org/10.1016/j.freeradbiomed.2007.03.024
206. Wu, D., & Meydani, S. N. (2014). Age-associated changes in immune function: impact of vitamin E intervention and the underlying mechanisms. Endocrine, metabolic & immune disorders drug targets, 14(4), 283–289. https://doi.org/10.2174/1871530314666140922143950
207. De la Fuente, M., Hernanz, A., Guayerbas, N., Victor, V. M., & Arnalich, F. (2008). Vitamin E ingestion improves several immune functions in elderly men and women. Free radical research, 42(3), 272–280. https://doi.org/10.1080/10715760801898838
208. Browne, D., McGuinness, B., Woodside, J. V., & McKay, G. J. (2019). Vitamin E and Alzheimer's disease: what do we know so far?. Clinical interventions in aging, 14, 1303–1317. https://doi.org/10.2147/CIA.S186760
390. Widaa, A., Brennan, O., O'Gorman, D. M., & O'Brien, F. J. (2014). The osteogenic potential of the marine-derived multi-mineral formula aquamin is enhanced by the presence of vitamin D. Phytotherapy Research, 28(5), 678-684. doi: 10.1002/ptr.5038
391.O'Callaghan, Y. C., Drummond, E., O'Gorman, D. M., & O'Brien, N. M. (2013). Antioxidant and pro-apoptotic effects of marine-derived, multi-mineral aquamin supplemented with a pine bark extract, Enzogenol, and a green tea extract, Sunphenon. Journal of Medicinal Food, 16(10), 920-926. doi: 10.1089/jmf.2012.0258
392. Crowley, E. K., Long-Smith, C. M., Murphy, A., Patterson, E., Murphy, K., O'Gorman, D. M., Stanton, C., & Nolan, Y. M. (2018). Dietary supplementation with a magnesium-rich marine mineral blend enhances the diversity of gastrointestinal microbiota. Marine Drugs, 16(6), 216. doi: 10.3390/md16060216
394.Cronin, B. E., Allsopp, P. J., Slevin, M. M., Magee, P. J., Livingstone, M. B. E., Strain, J. J., & McSorley, E. M. (2016). Effects of supplementation with a calcium-rich marine-derived multi-mineral supplement and short-chain fructo-oligosaccharides on serum lipids in postmenopausal women. British Journal of Nutrition, 115(4), 658-665. doi: 10.1017/S0007114515004948
395. Lee, E., Lim, Y., Kwon, S. W., & Kwon, O. (2019). Pinitol consumption improves liver health status by reducing oxidative stress and fatty acid accumulation in subjects with non-alcoholic fatty liver disease: A randomized, double-blind, placebo-controlled trial. The Journal of nutritional biochemistry, 68, 33–41. https://doi.org/10.1016/j.jnutbio.2019.03.006
400. Al-Yasiry, A. R., & Kiczorowska, B. (2016). Frankincense--therapeutic properties. Postepy higieny i medycyny doswiadczalnej (Online), 70, 380–391. https://doi.org/10.5604/17322693.1200553
